F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production.

ABSTRACT:

Background

Tumor-resident microbiota has been documented for various cancer types. Oral squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of microbiota in shaping the OSCC microenvironment remains elusive.

Methods

We used bioinformatics and clinical sample analysis to explore relationship between F. nucleatum and OSCC progression. Xenograft tumor model, metabolic screening and RNA sequencing were performed to elucidate mechanisms of pro-tumor role of F. nucleatum.

Findings

We show that a major protumorigenic bacterium, F. nucleatum, accumulates in invasive margins of OSCC tissues and drives tumor-associated macrophages (TAMs) formation. The mechanistic dissection shows that OSCC-resident F. nucleatum triggers the GalNAc-Autophagy-

SUBMITTER: Sun J 

PROVIDER: S-EPMC9900488 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature