Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis.

ABSTRACT: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components of the aberrant immune response have been investigated, comprehensive studies linking different data layers are lacking. Using an integrated systems immunology approach, we evaluated neutrophil phenotypes and concomitant changes in cytokines and metabolites in patients with sepsis. Our findings identify differentially expressed mature and immature neutrophil subsets in patients with sepsis. These subsets correlate with various proteins, metabolites, and lipids, including pentraxin-3, angiopoietin-2, and lysophosphatidylcholines, in patients with sepsis. The

SUBMITTER: Parthasarathy U 

PROVIDER: S-EPMC9900520 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature