A prospective study on serum citrate levels and clinical correlations in patients receiving regional citrate anticoagulation.

ABSTRACT:

Background

Current ways to diagnose citrate accumulation (CA) in patients receiving regional citrate anticoagulation (RCA) continuous renal replacement therapy (CRRT) are confounded by various clinical factors. Serum citrate measurement emerges as a more direct way to diagnose CA, but its clinical utility and optimal cut-off values remain undefined. This study examined serum citrate kinetics and its diagnostic performance for CA in patients receiving RCA CRRT.

Methods

A multicentre prospective study was carried out in two tertiary referral centre intensive care units in Hong Kong with serum citrate levels measured at baseline and 2, 6, 12, 24, 36, 48 and 72 h after initiation of RCA CRRT and their relationships with the development of CA.

Results

Among the 133 patient

SUBMITTER: To HHM 

PROVIDER: S-EPMC9900571 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature