Clinical significance of adjuvant chemotherapy for pathological complete response rectal cancer patients with acellular mucin pools after neoadjuvant chemoradiotherapy.

ABSTRACT:

Background

Approximately 15-30% of locally advanced rectal cancer (LARC) patients achieved pathological complete response (pCR) after neoadjuvant chemoradiotherapy (CRT) and total mesorectal excision, but the clinical significance of adjuvant chemotherapy (ACT) for pCR patients remains unclear.

Objectives

To determine whether LARC pCR patients can benefit from the administration of ACT.

Design

Single center retrospective study.

Methods

This study retrospectively included 280 LARC patients who achieved pCR after CRT and surgery from 2011 to 2019. The information of patients was recorded. Main outcome measures included 5-year disease-free survival (DFS) and 5-year overall survival. Subgroup analysis was conducted on whether pCR patients with acellular mucin pools

SUBMITTER: Chen M 

PROVIDER: S-EPMC9900662 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature