Effectiveness of oral versus intravenous tranexamic acid in primary total hip and knee arthroplasty: a randomised, non-inferiority trial.

ABSTRACT:

Background

Tranexamic acid (TXA) reduces rates of blood transfusion for total hip arthroplasty (THA) and total knee arthroplasty (TKA). Although the use of oral TXA rather than intravenous (i.v.) TXA might improve safety and reduce cost, it is not clear whether oral administration is as effective.

Methods

This noninferiority trial randomly assigned consecutive patients undergoing primary THA or TKA under neuraxial anaesthesia to either one preoperative dose of oral TXA or one preoperative dose of i.v. TXA. The primary outcome was calculated blood loss on postoperative day 1. Secondary outcomes were transfusions and complications within 30 days of surgery.

Results

Four hundred participants were randomised (200 THA and 200 TKA). The final analysis included 196 THA patie

SUBMITTER: DeFrancesco CJ 

PROVIDER: S-EPMC9900725 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature