Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis.

ABSTRACT:

Background and objective

PCOS is a common metabolic disorder in women of reproductive age, which pathogenesis is very complex. The role of ferroptosis in PCOS is a novel finding, and the mechanistic studies are not clear. Metformin is a commonly used drug of PCOS but few studies on whether metformin can improve the follicle development and ovarian function in PCOS. We aims to use PCOS mouse model to study the effect of metformin on PCOS based on the ovarian function and explored the regulation of metformin in PCOS mice by intervening in ferroptosis pathway.

Materials and methods

C57 BL/6J female mice aged 4-5 weeks were purchased and gavaged with letrozole (1 mg/kg/day) combined with high-fat diet for 21days to establish PCOS model, and control group was set up. After modeli

SUBMITTER: Peng Q 

PROVIDER: S-EPMC9900736 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature