Impact of cross-ancestry genetic architecture on GWAS in admixed populations.

ABSTRACT: Genome-wide association studies (GWAS) have identified thousands of variants for disease risk. These studies have predominantly been conducted in individuals of European ancestries, which raises questions about their transferability to individuals of other ancestries. Of particular interest are admixed populations, usually defined as populations with recent ancestry from two or more continental sources. Admixed genomes contain segments of distinct ancestries that vary in composition across individuals in the population, allowing for the same allele to induce risk for disease on different ancestral backgrounds. This mosaicism raises unique challenges for GWAS in admixed populations, such as the need to correctly adjust for population stratification to balance type I error with statistical p

SUBMITTER: Mester R 

PROVIDER: S-EPMC9900755 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature