Feeding Neurons Integrate Metabolic and Reproductive States in Mice.

ABSTRACT: Trade-offs between metabolic and reproductive processes are important for survival, particularly in mammals that gestate their young. Puberty and reproduction, as energetically taxing life stages, are often gated by metabolic availability in animals with ovaries. How the nervous system coordinates these trade-offs is an active area of study. We identify somatostatin neurons of the tuberal nucleus (TN^SST) as a node of the feeding circuit that alters feeding in a manner sensitive to metabolic and reproductive states in mice. Whereas chemogenetic activation of TN^SST neurons increased food intake across sexes, selective ablation decreased food intake only in female mice during proestrus. Interestingly, this ablation effect was only apparent in animals with a low body mass

SUBMITTER: Massa MG 

PROVIDER: S-EPMC9900829 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature