Cell-type-specific inhibitory circuitry from a connectomic census of mouse visual cortex.

ABSTRACT: Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic anatomical, molecular and functional properties. Synaptic connectivity powerfully shapes how each cell type participates in the cortical circuit, but mapping connectivity rules at the resolution of distinct cell types remains difficult. Here, we used millimeter-scale volumetric electron microscopy¹ to investigate the connectivity of all inhibitory neurons across a densely-segmented neuronal population of 1352 cells spanning all layers of mouse visual cortex, producing a wiring diagram of inhibitory connections with more than 70,000 synapses. Taking a data-driven approach inspired by classical neuroanatomy, we classified inhibitory neurons based on the relative targeting of dendritic compa

SUBMITTER: Schneider-Mizell CM 

PROVIDER: S-EPMC9900837 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature