Exercise as an augmentation treatment for nonremitted major depressive disorder: a randomized, parallel dose comparison.

ABSTRACT:

Objective

Most patients with major depressive disorder (MDD) require second-step treatments to achieve remission. The Treatment with Exercise Augmentation for Depression (TREAD) study was designed to test the efficacy of aerobic exercise as an augmentation treatment for MDD patients who had not remitted with antidepressant treatment.

Method

Eligible participants in this randomized controlled trial were sedentary individuals (men and women aged 18-70 years) diagnosed with DSM-IV nonpsychotic MDD who had not remitted with selective serotonin reuptake inhibitor (SSRI) treatment. Participants were recruited through physician referrals and advertisements. A total of 126 participants were randomized to augmentation treatment with either 16 kcal per kg per week (KKW) or 4 KKW of ex

SUBMITTER: Trivedi MH 

PROVIDER: S-EPMC9900872 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature