The Ontology of Biological Attributes (OBA) - Computational Traits for the Life Sciences.

ABSTRACT: Existing phenotype ontologies were originally developed to represent phenotypes that manifest as a character state in relation to a wild-type or other reference. However, these do not include the phenotypic trait or attribute categories required for the annotation of genome-wide association studies (GWAS), Quantitative Trait Loci (QTL) mappings or any population-focused measurable trait data. Moreover, variations in gene expression in response to environmental disturbances even without any genetic alterations can also be associated with particular biological attributes. The integration of trait and biological attribute information with an ever increasing body of chemical, environmental and biological data greatly facilitates computational analyses and it is also highly relevant to biomedic

SUBMITTER: Stefancsik R 

PROVIDER: S-EPMC9900877 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature