Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness.

ABSTRACT: The cumulative effects of T cell receptor (TCR) signal transduction over extended periods of time influences T cell biology, such as the positive selection of immature thymocytes or the proliferative responses of naive T cells. Naive T cells experience recurrent TCR signaling in response to self-antigens in the steady state. However, how these signals influence the responsiveness of naive CD8⁺ T cells to subsequent agonist TCR stimulation remains incompletely understood. We investigated how naive CD8⁺ T cells that experienced relatively low or high levels of TCR signaling in response to self-antigens respond to stimulation with foreign antigens. A transcriptional reporter of Nr4a1 (Nur77-GFP) revealed substantial heterogeneity of the amount of TCR signaling nai

SUBMITTER: Eggert J 

PROVIDER: S-EPMC9900884 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature