Characterization of the zebrafish <i>gabra1</i>^{<i>sa43718/sa43718</i>} germline loss of function allele confirms a function for Gabra1 in motility and nervous system development.

ABSTRACT: Mutation of the GABRA1 gene is associated with neurodevelopmental defects and epilepsy. GABRA1 encodes for the α1 subunit of the gamma-aminobutyric acid type A receptor (GABA_AR), which regulates the fast inhibitory impulses of the nervous system. Multiple model systems have previously been developed to understand the function of GABRA1 during development, but these models have produced complex and at times incongruent data. Thus, additional model systems are required to validate and substantiate previously published results. We investigated the behavioral swim patterns associated with a nonsense mutation of the zebrafish gabra1 (sa43718 allele) gene. The sa43718 allele causes a decrease in gabra1 mRNA expression, which is associat

SUBMITTER: Paz D 

PROVIDER: S-EPMC9900897 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature