Frailty and its combined effects with lifestyle factors on cognitive function: a cross-sectional study.

ABSTRACT:

Background

Frailty describes an age-related state of deterioration in biological function. This study aimed to investigate the association between frailty and cognitive function and its combined effects with lifestyles.

Methods

A total of 3,279 participants from the Dongfeng-Tongji (DFTJ) cohort were tested the cognitive function by using the Chinese version of Mini-mental State Examination (MMSE). Frailty was evaluated based on a 35-item frailty index (FI). Frailty status was dichotomized into robust (FI < 0.15) and frail (FI ≥ 0.15). Multivariate generalized linear regression models and logistic regression models were used to estimate the associations of frailty with MMSE score and cognitive impairment. We also analysed the modification and combined effects of lifestyle fa

SUBMITTER: Li F 

PROVIDER: S-EPMC9900934 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature