Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.

ABSTRACT: Mycobacterium tuberculosis is currently the leading cause of death by any bacterial infection¹. The mycolic acid layer of the cell wall is essential for viability and virulence, and the enzymes responsible for its synthesis are therefore front line targets for antimycobacterial drug development^2,3. Polyketide synthase 13 (Pks13) is a module comprised of a closely symmetric parallel dimer of chains, each encoding several enzymatic and transport functions, that carries out the condensation of two different very long chain fatty acids to produce mycolic acids that are essential components of the mycobacterial cell wall. Consequently individual enzymatic domains of Pks13 are targets for antimycobacterial drug development⁴. To understand this machinery, w

SUBMITTER: Kim SK 

PROVIDER: S-EPMC9900942 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature