Lost in space(s): multimodal neuroimaging of disorientation along the Alzheimer's disease continuum.

ABSTRACT: Orientation is a fundamental cognitive faculty, allowing the behaving self to link his/her current state to their internal representations of the external world. Once exclusively linked to knowledge of the current place and present time, in recent years, the concept of orientation has evolved to include processing of social, temporal, and abstract relations. Concordantly with the growing focus on orientation, spatial disorientation has been increasingly recognized as a hallmark symptom of Alzheimer's disease (AD). However, few studies have sought to explore disorientation along the AD continuum beyond the spatial domain. 51 participants along the AD continuum performed an orientation task in the spatial, temporal and social domains. Under functional magnetic resonance imaging (fMRI), parti

SUBMITTER: Peters-Founshtein G 

PROVIDER: S-EPMC9900945 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature