A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors.

ABSTRACT:

Background

IMP2 and IMP3 are mRNA binding proteins involved in carcinogenesis. We examined a large cohort of ovarian tumors with the aim to assess the value of IMP2 and IMP3 for differential diagnosis, and to assess their prognostic significance.

Methods

Immunohistochemical analyses with antibodies against IMP2 and IMP3 were performed on 554 primary ovarian tumors including 114 high grade serous carcinomas, 100 low grade serous carcinomas, 124 clear cell carcinomas, 54 endometrioid carcinomas, 34 mucinous carcinomas, 75 mucinous borderline tumors, and 41 serous borderline tumors (micropapillary variant). The associations of overall positivity with clinicopathological characteristics were evaluated using the chi-squared test or Fisher's Exact test.

Results

We found IMP

SUBMITTER: Nemejcova K 

PROVIDER: S-EPMC9901072 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature