Chondroitin sulfate alleviates osteoporosis caused by calcium deficiency by regulating lipid metabolism.

ABSTRACT: The use of non-drug intervention for calcium deficiency has attracted attention in recent years. Although calcium carbonate is the preferred raw material for calcium supplementation, there are few reports on the mechanism of the combined action of chondroitin sulfate and calcium to alleviate osteoporosis from the perspective of gut microbiota and metabolomics. In this study, a rat model of osteoporosis was established by feeding a low-calcium diet. The intestinal microbiota abundance, fecal and plasma metabolite expression levels of rats fed a basal diet, a low-calcium diet, a low-calcium diet plus calcium carbonate, and a low-calcium diet plus chondroitin sulfate were compared. The results showed that compared with the low calcium group, the calcium content and bone mineral density of fem

SUBMITTER: Liu T 

PROVIDER: S-EPMC9901125 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature