Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma.

ABSTRACT:

Background

Infantile hemangioma (IH) is the most common tumor among infants, but the exact pathogenesis of IH is largely unknown. Our previous study revealed that glucose metabolism may play an important role in the pathogenesis of IH and that the inhibition of the glycolytic key enzyme phosphofructokinase-1 suppresses angiogenesis in IH. 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is a metabolic enzyme that converts fructose-6-bisphosphate to fructose-2,6-bisphosphate (F-2,6-BP), which is the most potent allosteric activator of the rate-limiting enzyme phosphofructokinase-1. This study was performed to explore the role of PFKFB3 in IH.

Methods

Microarray analysis was performed to screen the differentially expressed genes (DEGs) between proliferating and i

SUBMITTER: Yang K 

PROVIDER: S-EPMC9901151 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature