Temporal endurance of exercise-induced benefits on hippocampus-dependent memory and synaptic plasticity in female mice.

ABSTRACT: Exercise facilitates hippocampal neurogenesis and neuroplasticity that in turn, promotes cognitive function. Our previous studies have demonstrated that in male mice, voluntary exercise enables hippocampus-dependent learning in conditions that are normally subthreshold for long-term memory formation in sedentary animals. Such cognitive enhancement can be maintained long after exercise has ceased and can be re-engaged by a subsequent subthreshold exercise session, suggesting exercise-induced benefits are temporally dynamic. In females, the extent to which the benefits of exercise can be maintained and the mechanisms underlying this maintenance have yet to be defined. Here, we examined the exercise parameters required to initiate and maintain the benefits of exercise in female C57BL/6J mice.

SUBMITTER: Dong TN 

PROVIDER: S-EPMC9901197 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature