Network-based quantitative trait linkage analysis of microbiome composition in inflammatory bowel disease families.

ABSTRACT: Introduction: Inflammatory bowel disease (IBD) is characterized by a dysbiosis of the gut microbiome that results from the interaction of the constituting taxa with one another, and with the host. At the same time, host genetic variation is associated with both IBD risk and microbiome composition. Methods: In the present study, we defined quantitative traits (QTs) from modules identified in microbial co-occurrence networks to measure the inter-individual consistency of microbial abundance and subjected these QTs to a genome-wide quantitative trait locus (QTL) linkage analysis. Results: Four microbial network modules were consistently identified in two cohorts of healthy individuals, but three of the corresponding QTs differed significantly between IBD patients and unaf

SUBMITTER: Sharma A 

PROVIDER: S-EPMC9901208 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature