Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4⁺ T cells.

ABSTRACT: The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but was initially identified as the lineage-specifying transcription factor of Th1 CD4⁺ T cells, where it governs expression of the signature cytokine IFN- γ and represses alternative cell fates like Th2 and Th17. T-bet's paralog Eomes is less abundantly expressed and Eomes⁺ CD4⁺ T cells are mostly found in the context of persistent antigen exposure, like bone marrow transplantation, chronic infection or inflammation as well as malignant disorders. However, it has remained unresolved whether Eomes executes similar transcriptional activities as T-bet in CD4⁺ T cells. Here we use

SUBMITTER: Thelen B 

PROVIDER: S-EPMC9901365 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature