Skeletal muscle area predicts the outcomes of non-small-cell lung cancer after trimodality therapy

ABSTRACT: Abstract

OBJECTIVES

Sarcopenia correlates with poor prognosis in various malignancies. However, the prognostic significance of sarcopenia remains to be determined in patients with non-small-cell lung cancer who undergo surgery after receiving neoadjuvant chemoradiotherapy (NACRT).

METHODS

We retrospectively reviewed the patients with stage II/III non-small-cell lung cancer who underwent surgery following NACRT. The paravertebral skeletal muscle area (SMA) (cm2) at the 12th thoracic vertebra level was measured. We calculated the SMA index (SMAI) as SMA/squared height (cm2/m2). Patients were divided into low and high SMAI groups, and the association of SMAI with clinicopathological factors and prognosis was assessed.

RESULTS

The patients’ [men, 86 (81.1%)] median

SUBMITTER:  

PROVIDER: S-EPMC9901413 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature