A comprehensive framework for evaluation of high pacing frequency and arrhythmic optical mapping signals.

ABSTRACT: Introduction: High pacing frequency or irregular activity due to arrhythmia produces complex optical mapping signals and challenges for processing. The objective is to establish an automated activation time-based analytical framework applicable to optical mapping images of complex electrical behavior. Methods: Optical mapping signals with varying complexity from sheep (N = 7) ventricular preparations were examined. Windows of activation centered on each action potential upstroke were derived using Hilbert transform phase. Upstroke morphology was evaluated for potential multiple activation components and peaks of upstroke signal derivatives defined activation time. Spatially and temporally clustered activation time points were grouped in to wave fronts for individual pr

SUBMITTER: Ramlugun GS 

PROVIDER: S-EPMC9901579 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature