The role of the T-cell mediated immune response to Cytomegalovirus infection in intrauterine transmission.

ABSTRACT:

Introduction

Prognostic markers for fetal transmission of Cytomegalovirus (CMV) infection during pregnancy are poorly understood. Maternal CMV-specific T-cell responses may help prevent fetal transmission and thus, we set out to assess whether this may be the case in pregnant women who develop a primary CMV infection.

Methods

A multicenter prospective study was carried out at 8 hospitals in Spain, from January 2017 to April 2020. Blood samples were collected from pregnant women at the time the primary CMV infection was diagnosed to assess the T-cell response. Quantitative analysis of interferon producing specific CMV-CD8+/CD4+ cells was performed by intracellular cytokine flow cytometry.

Results

In this study, 135 pregnant women with a suspected CMV infection were eva

SUBMITTER: Soriano-Ramos M 

PROVIDER: S-EPMC9901742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature