The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial.

ABSTRACT:

Objective

We hypothesize that synbiotic supplementation could modulate the intestinal microbiota and subsequently, improve the condition of hypothyroid patients.

Methods

Fifty-six adult hypothyroid patients were recruited to this double-blind, placebo-controlled, randomized clinical trial. The intervention was 10 weeks of synbiotic (500 mg of 109 CFU/g probiotics plus fructo-oligosaccharide, n = 28) compared to placebo (lactose, magnesium stearate, talc, and silicon dioxide, n = 28). Randomization and allocation to trial groups were carried out using random number sequences drawn from https://sealedenvelope.com/. Primary outcomes were serum thyroid stimulating hormone (TSH) and free thyroxine (FT4), and secondary outcomes were depression, quality of life, and blood pressure

SUBMITTER: Ramezani M 

PROVIDER: S-EPMC9901790 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature