Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer.

ABSTRACT: Although brown fat is strongly associated with a constellation of cardiometabolic benefits in animal models and humans, it has also been tied to cancer cachexia. In humans, cancer-associated cachexia increases mortality, raising the possibility that brown fat in this context may be associated with increased cancer death. However, the effect of brown fat on cancer-associated cachexia and survival in humans remains unclear. Here, we retrospectively identify patients with and without brown fat on fluorodeoxyglucose (¹⁸F-FDG) positron-emission tomography (PET) scans obtained as part of routine cancer care and assemble a cohort to address these questions. We did not find an association between brown fat status and cachexia. Furthermore, we did not observe an association between brown

SUBMITTER: Eljalby M 

PROVIDER: S-EPMC9902220 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature