Clinical, cognitive, and morphometric profiles of progressive supranuclear palsy phenotypes.

ABSTRACT: The International Parkinson's and Movement Disorder Society (MDS) criteria for progressive supranuclear palsy (PSP) have broadened the clinical spectrum of the disease and established phenotypic characterization according to the predominant manifestation at onset. The objective of this study is to describe clinical/cognitive and imaging features of a monocentric cohort of PSP patients, highlighting different patterns of functional disability according to the assigned phenotype. We retrospectively reviewed clinical/imaging data of 53 PSP patients diagnosed with probable PSP according to the MDS criteria and 40 age/sex-matched healthy controls (HCs). Neurological/neuropsychological assessments were performed using standardized scales, as well as comprehensive magnetic resonance imaging (MRI)

SUBMITTER: Campagnolo M 

PROVIDER: S-EPMC9902314 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature