Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease.

ABSTRACT:

Introduction

Aerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.

Objective

To investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer's disease (AD).

Methods

This is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer's disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention.

Results

A tot

SUBMITTER: Frederiksen KS 

PROVIDER: S-EPMC9902368 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature