Are higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?

ABSTRACT:

Purpose

Antidepressants are well-established fall-risk increasing drugs (FRIDs) and therefore falls should be considered an important adverse drug event (ADE) of antidepressants. However, not all antidepressant users experience fall incidents and factors associated with increased fall risk among antidepressant users are incompletely understood. Our objective was to explore whether antidepressant plasma concentrations are associated with falls in older antidepressant users.

Methods

For this study, we included antidepressant users of the multicenter B-PROOF study. Fall incidents were recorded prospectively using fall calendars. Antidepressant plasma concentrations were analyzed by Liquid chromatography-mass spectrometry (LC-MS) at baseline and at 2 years follow-up. The associa

SUBMITTER: Pronk AC 

PROVIDER: S-EPMC9902404 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature