Dosimetry and efficacy of a tau PET tracer [¹⁸F]MK-6240 in Japanese healthy elderly and patients with Alzheimer's disease.

ABSTRACT:

Objective

A new tau PET tracer [¹⁸F]MK-6240 has been developed; however, its dosimetry and pharmacokinetics have been published only for a European population. This study investigated the safety, radiation dosimetry, pharmacokinetics and biodistribution of [¹⁸F]MK-6240 in Japanese elderly subjects. Also, the pattern and extent of brain retention of [¹⁸F]MK-6240 in Japanese healthy elderly subjects and patients with Alzheimer's disease (AD) were investigated. These Japanese results were compared with previous reports on non-Japanese.

Methods

Three healthy elderly subjects and three AD patients were enrolled. Dynamic whole-body PET scans were acquired for up to 232 min after starting injection of [¹⁸F]MK-6240 (370.4 ± 27.0 MBq) for t

SUBMITTER: Ohnishi A 

PROVIDER: S-EPMC9902412 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature