Spatial distribution of metabolites in the retina and its relevance to studies of metabolic retinal disorders.

ABSTRACT:

Introduction

The primate retina has evolved regional specialisations for specific visual functions. The macula is specialised towards high acuity vision and is an area that contains an increased density of cone photoreceptors and signal processing neurons. Different regions in the retina display unique susceptibility to pathology, with many retinal diseases primarily affecting the macula.

Objectives

To better understand the properties of different retinal areas we studied the differential distribution of metabolites across the retina.

Methods

We conducted an untargeted metabolomics analysis on full-thickness punches from three different regions (macula, temporal peri-macula and periphery) of healthy primate retina.

Results

Nearly half of all metabolites identif

SUBMITTER: Bonelli R 

PROVIDER: S-EPMC9902429 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature