Cerebro-cerebellar functional neuroplasticity mediates the effect of electric field on electroconvulsive therapy outcomes.

ABSTRACT: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression and works by applying an electric current through the brain. The applied current generates an electric field (E-field) and seizure activity, changing the brain's functional organization. The E-field, which is determined by electrode placement (right unilateral or bitemporal) and pulse amplitude (600, 700, or 800 milliamperes), is associated with the ECT response. However, the neural mechanisms underlying the relationship between E-field, functional brain changes, and clinical outcomes of ECT are not well understood. Here, we investigated the relationships between whole-brain E-field (E_brain, the 90^th percentile of E-field magnitude in the brain), cerebro-cerebellar functional network

SUBMITTER: Fu Z 

PROVIDER: S-EPMC9902462 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature