FcγRIIIA activation-mediated up-regulation of glycolysis alters MDSCs modulation in CD4⁺ T cell subsets of Sjogren syndrome.

ABSTRACT: Our and other researchers' previous studies found that myeloid-derived suppressor cells (MDSCs) were increased, and these MDSCs, supposed to play immunosuppressive roles, showed significant pro-inflammatory effects in Sjögren's syndrome (SS). However, the key factors and potential mechanisms leading MDSCs to be inflammatory remain unclear. In this study, we found that MDSCs from SS patients were positively correlated with the percentages of Th17 cells, disease activity and serum autoantibodies, and showed higher levels of Fc gamma receptor (FcγR) IIIA and glycolysis. Most importantly, SS MDSCs or heat-aggregated IgG (HAIG)-treated MDSCs down-regulated Th1/Th2 ratio and up-regulated Th17/Treg ratio, which could be obviously rescued by IgG monomer or glycolysis inhibitor 2-DG. As well, the l

SUBMITTER: Qi J 

PROVIDER: S-EPMC9902521 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature