Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils.

ABSTRACT:

Background

Immunotherapy of gastrointestinal cancers is challenging; however, several lines of evidence suggest that adoptive transfer of stimulated or modified immune cells support not only protective role of immune cells in tumor microenvironment, but actively participate in the elimination of cancer cells.

Methods

In vivo studies employing cancer cell-derived allograft murine models of gastrointestinal cancers were performed. The effects of T helper (Th) 2 cells on gastrointestinal cancers growth and tumor microenvironment composition using adoptive transfer of Th2 cells, interleukin (IL)-5 treatment, and immunofluorescence, multiplex and real-time PCR were explored.

Results

Here, we show that Th2 cells play an essential role in the inhibition of colon and pancreas

SUBMITTER: Jacenik D 

PROVIDER: S-EPMC9902541 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature