Monocyte subsets and monocyte-related chemokines in Takayasu arteritis.

ABSTRACT: The pathogenesis of Takayasu arteritis (TAK) is poorly understood and no previous studies have analyzed monocytes in TAK. This study evaluated monocyte subsets and monocyte-related chemokines in the peripheral blood of TAK patients and healthy controls (HC). Monocyte subsets were identified as classical (CD14⁺CD16^-), intermediate (CD14⁺CD16^dim), and non-classical (CD14^dimCD16^high) in the peripheral blood. The chemokines CCL (C-C chemokine ligand)2, CCL3, CCL4, CCL5, CCL7, CXCL (C-X-C motif ligand)10, and CX3CL (C-X3-C motif ligand)1 were measured in the sera. Thirty-two TAK patients and 30 HC were evaluated. Intermediate monocytes were higher in TAK than HC [25.0 cells ×10⁶/L (16.7-52.0) vs. 17.2 cells ×10^6</

SUBMITTER: de Aguiar MF 

PROVIDER: S-EPMC9902560 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature