Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia.

ABSTRACT: Genetic studies in psychiatry have primarily focused on the effects of common genetic variants, but few have investigated the role of rare genetic variants, particularly for major depression. In order to explore the role of rare variants in the gap between estimates of single nucleotide polymorphism (SNP) heritability and twin study heritability, we examined the contribution of common and rare genetic variants to latent traits underlying psychiatric disorders using high-quality imputed genotype data from the UK Biobank. Using a pre-registered analysis, we used items from the UK Biobank Mental Health Questionnaire relevant to three psychiatric disorders: major depression (N = 134,463), bipolar disorder (N = 117,376) and schizophrenia (N = 130,013) and identified a general hierarchical facto

SUBMITTER: Dattani S 

PROVIDER: S-EPMC9902570 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature