Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes.

ABSTRACT: Transposable elements (TEs) are major contributors of genetic material in mammalian genomes. These often include binding sites for architectural proteins, including the multifarious master protein, CTCF, which shapes the 3D genome by creating loops, domains, compartment borders, and RNA-DNA interactions. These play a role in the compact packaging of DNA and have the potential to facilitate regulatory function. In this study, we explore the widespread contribution of TEs to mammalian 3D genomes by quantifying the extent to which they give rise to loops and domain border differences across various cell types and species using several 3D genome mapping technologies. We show that specific families and subfamilies of TEs have contributed to lineage-specific 3D chromatin structures across mammal

SUBMITTER: Choudhary MNK 

PROVIDER: S-EPMC9902604 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature