Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome.

ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS) is a disease leading to spontaneous abortions and stillbirths in sows and lowered life quality and expectancy in growing pigs. PRRS is prevalent worldwide and has significant economic impacts to swine industries around the globe. Co-expression of the two most abundant proteins in the viral envelope, the matrix protein (M) and glycosylated protein 5 (GP5), can produce a neutralizing immune response for the virus providing a potentially effective subunit vaccine against the disease, but these proteins are difficult to express. The goal of this research was to display antigenic portions of the M and GP5 proteins on the surface of tobacco mosaic virus-like particles. A modified tobacco mosaic virus coat protein (TMVc) was transiently express

SUBMITTER: VanderBurgt JT 

PROVIDER: S-EPMC9902946 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature