Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.

ABSTRACT: Central nervous system tumors, especially astrocytomas, are the solid neoplasms with the highest incidence and mortality rates in childhood. The diagnosis is based on histopathological characteristics, but molecular methods have been increasingly used. Translationally controlled tumor protein (TCTP) protein, encoded by the tumor protein, translationally controlled 1 (TPT1) gene, is a multifunctional protein with an important physiological role in the cell cycle. Expression of this protein has been associated with several neoplasms, including astrocytomas in adults. However, the role of this protein in pediatric astrocytomas is largely unknown. We aim to evaluate in cases of pediatric astrocytomas, the frequency of polymorphisms in the TPT1 gene and other genes associated with

SUBMITTER: Morais de Castro E 

PROVIDER: S-EPMC9903018 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature