Fixed-dose combination therapy-based protocol compared with free pill combination protocol: Results of a cluster randomized trial.

ABSTRACT: Fixed-dose combination (FDC) therapy is recommended for hypertension management in Nigeria based on randomized trials at the individual level. This cluster-randomized trial evaluates effectiveness and safety of a treatment protocol that used two-drug FDC therapy as the second and third steps for hypertension control compared with a protocol that used free pill combinations. From January 2021 to June 2021, 60 primary healthcare centers in the Federal Capital Territory of Nigeria were randomized to a protocol using FDC therapy as second and third steps compared with a protocol that used the same medications in free pill combination therapy for these steps. Eligible patients were adults (≥18 years) with hypertension. The primary outcome was the odds of a patient being controlled at their last

SUBMITTER: Sanuade OA 

PROVIDER: S-EPMC9903187 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature