IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.

ABSTRACT: Adult neurogenesis is supported by multipotent neural stem cells (NSCs) with unique properties and growth requirements. Adult NSCs constitute a reversibly quiescent cell population that can be activated by extracellular signals from the microenvironment in which they reside in vivo. Although genomic imprinting plays a role in adult neurogenesis through dose regulation of some relevant signals, the roles of many imprinted genes in the process remain elusive. Insulin-like growth factor 2 (IGF2) is encoded by an imprinted gene that contributes to NSC maintenance in the adult subventricular zone through a biallelic expression in only the vascular compartment. We show here that IGF2 additionally promotes terminal differentiation of NSCs into astrocytes, neurons and oligodendrocytes by inducing

SUBMITTER: Lozano-Urena A 

PROVIDER: S-EPMC9903205 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature