Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan.

ABSTRACT: The choroid plexus (ChP) comprises a collection of modified ependymal cells that play an important role in the production of brain cerebrospinal fluid (CSF), and ChP perfusion aberrations have been implicated in a range of cerebrovascular and neurodegenerative disorders. To provide an exemplar for the growing interest in ChP activity, we evaluated ChP perfusion and bulk CSF flow cross-sectionally across the healthy adult lifespan. Participants (n = 77; age range = 21-86 years) were scanned at 3T using T₁-weighted, T₂-weighted-FLAIR, perfusion-weighted pCASL, and phase contrast MRI to calculate ChP anatomy, perfusion, and aqueductal CSF flow, respectively. Regression models were applied to evaluate aging effects on ChP volume and ChP perfusion in the late

SUBMITTER: Eisma JJ 

PROVIDER: S-EPMC9903224 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature