Altered dynamic functional architecture in type 2 diabetes mellitus.

ABSTRACT:

Introduction

Type 2 diabetes mellitus (T2DM) can accelerate cognitive decline and even dementia so that the underlying mechanism deserves further exploration. In the resting state, brain function is still changing dynamically. At present, it is still unknown whether the dynamic functional connectivity (dFC) between various brain regions is in a stable state. It is necessary to interpret brain changes from a new perspective, that is, the stability of brain architecture.

Methods

In this study, we used a fixed dynamic time scale to explore the stability of dynamic functional architecture in T2DM, then the dynamic effective connectivity (dEC) was used to further explain how information flows through dynamically fluctuating brain architecture in T2DM.

Result

Two brain regi

SUBMITTER: Li Y 

PROVIDER: S-EPMC9903314 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature