Synthesis of Nonsymmetrically Substituted 2,3-Dialkoxyphenazine Derivatives and Preliminary Examination of Their Cytotoxicity.

ABSTRACT: Fourteen new 2,3-dialkoxyphenazine derivatives with two different alkoxy groups bearing R¹ and R² alkyl chains, defined as -CH₂CH(CH₃)₂ and -(CH₂)_n-1CH₃ for n = 1, 2, 4, 6, 8, and 10, were prepared via regioselective synthesis. The applied synthetic protocol is based on the following reactions: the Buchwald-Hartwig coupling of a nonsymmetrically substituted 4,5-dialkoxy-2-nitroaniline with a 1-bromo-2-nitrobenzene derivative featuring additional tert-butyl, trifluoromethyl or two methoxy groups; the reduction of bis(2-nitrophenyl)amine; and a final step of tandem-like oxidation that leads to the preparation of a heterocyclic phenazine system. The regioselectivity of these ste

SUBMITTER: Reka P 

PROVIDER: S-EPMC9903326 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature