Morphine counteracts the effects of paclitaxel in triple-negative breast cancer cells.

ABSTRACT:

Background & objectives

Several studies have provided evidence that opioids may play a role in cancer recurrence and metastasis. Multiple research data indicate that morphine can act as a proliferative or suppressive agent on tumour cells depending on the applied concentration. Therefore, this study was aimed to investigate whether the presence of clinically relevant concentrations of morphine has any effect on the efficacy of paclitaxel, a widely used chemotherapeutic drug, on the viability and apoptosis of human triple-negative breast cancer cell line.

Methods

MDA.MB.231 cells were treated with paclitaxel in the presence or absence of morphine and examined for cell proliferation by the MTT assay. In addition, the effect of morphine on paclitaxel-induced apoptosis was inves

SUBMITTER: Sezer G 

PROVIDER: S-EPMC9903376 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature