Cortico-subcortical interactions in overlapping communities of edge functional connectivity.

ABSTRACT: Both cortical and subcortical regions can be functionally organized into networks. Regions of the basal ganglia are extensively interconnected with the cortex via reciprocal connections that relay and modulate cortical function. Here we employ an edge-centric approach, which computes co-fluctuations among region pairs in a network to investigate the role and interaction of subcortical regions with cortical systems. By clustering edges into communities, we show that cortical systems and subcortical regions couple via multiple edge communities, with hippocampus and amygdala having a distinct pattern from striatum and thalamus. We show that the edge community structure of cortical networks is highly similar to one obtained from cortical nodes when the subcortex is present in the network. Addi

SUBMITTER: Chumin EJ 

PROVIDER: S-EPMC9903436 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature