Association of plasma lipid metabolism profiles with overall survival for patients with gastric cancer undergoing gastrectomy based on ¹H-NMR spectroscopy.

ABSTRACT:

Background

Lipid metabolism dysregulation is a prominent metabolic alteration in various cancers. The study aimed to explore the association of plasma lipid metabolism profiles with overall survival (OS) for gastric cancer (GC) patients who received gastrectomy.

Methods

GC patients who were treated with gastrectomy and measured with plasma lipid metabolism profiles using proton nuclear magnetic resonance (¹H-NMR) spectroscopy in Nanfang Hospital between January 1, 2017, and October 31, 2018, were recruited. The Least Absolute Shrinkage and Selection Operator (LASSO) regression model was used to analyze variables selected by univariate analysis for OS. An index of plasma lipid metabolism profiles, named plasma lipid metabolism index (PLMI), was constructed by varia

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC9903497 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature