Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma.

ABSTRACT:

Background

Cuproptosis is a new type of copper-induced cell death that is characterized by the aggregation of lipoylated tricarboxylic acid (TCA) cycle proteins. However, its role in hepatocellular carcinoma (HCC) remains unclear. The goal of this research is to develop a cuproptosis-related signature predicting the prognosis of HCC.

Methods

The cuproptosis-related genes were defined using Pearson correlation coefficients. LASSO-Cox regression analysis was used to evaluate the prognostic values of cuproptosis-related genes to construct a cuproptosis-related prognostic model. The immune microenvironment analysis was performed by "ssGSEA" to reveal the associated immune cell infiltration patterns with the cuproptosis-related genes signature. The expression levels of one of the

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9903524 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature