HELLPAR/RRM2 axis related to HMMR as novel prognostic biomarker in gliomas.

ABSTRACT:

Background

Gliomas are the most frequent type of central nervous system tumor, accounting for more than 70% of all malignant CNS tumors. Recent research suggests that the hyaluronan-mediated motility receptor (HMMR) could be a novel potential tumor prognostic marker. Furthermore, mounting data has highlighted the important role of ceRNA regulatory networks in a variety of human malignancies. The complexity and behavioural characteristics of HMMR and the ceRNA network in gliomas, on the other hand, remained unknown.

Methods

Transcriptomic expression data were collected from TCGA, GTEx, GEO, and CGGA database.The relationship between clinical variables and HMMR was analyzed with the univariate and multivariate Cox regression. Kaplan-Meier method was used to assess OS. TCGA dat

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9903609 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature